Effectiveness of Exogenous Melatonin in Insomnia

• WOO YUN KIN

 

CHAPTER 1

What Citation Formats Do You Support?

We hear “Can you write in APA or MLA?” all the time—and the answer’s a big yes, plus way more! Our writers are wizards with every style—APA, MLA, Harvard, Chicago, Turabian, you name it—delivering flawless formatting tailored to your assignment. Whether it’s a tricky in-text citation or a perfectly styled reference list, they’ve got the skills to make your paper academically spot-on.

INTRODUCTION

1. Research Background

Sleep is not always a luxury. Insomnia is defined as a sleep disorder in which there is an inability to fall asleep or stay asleep as long as desired (Roth T. 2007). It is estimated that up to 34% of adults in the United States and 37% in Europe have some forms of insomnia (Leger D. 2005). Insomnia can be classified to mild, moderate and severe according to the International Classification of Sleep Disorder (ICSD).

Melatonin (5-methoxy-N-acetyltryptamine) is a lipid soluble hormone secreted by the pineal gland during hours of darkness. Melatonin has several physiological functions including regulation of the circadian rhythms, modulation of seasonal change and a powerful antioxidant (Gitto et al. 2013). With age, it has been shown that the 24hour melatonin secretion is significantly reduced thus affecting the normal circadian cycle (Iguchi et al. 1982).

At present, insomnia is typically treated symptomatically, often with benzodiazepine or antidepressants. However chronic insomnia requires long term treatment which may cause significant side effects and unwanted drug-drug interaction. Approximately 29-61% of older adults with insomnia complaints have preexisting sleep apnea (Krakow et al. 2001). With the combination of insomnia and sleep apnea, sedative-hypnotic treatments may worsen the sleep apnea (Mendelson et al. 1981).

Are Paper Services Legal?

Yes, completely! They’re a valid tool for getting sample papers to boost your own writing skills, and there’s nothing shady about that. Use them right—like a study guide or a model to learn from—and they’re a smart, ethical way to level up your grades without breaking any rules.

Exogenous melatonin is a chronobiotic drug with some hypnotic properties (Zhdanova et al. 1997), it has become of the most frequently non-prescribed sleep aid due to its role in regulating and promoting sleep (Wagner et al. 1998). some studies have shown that supplemental melatonin can increase sleep propensity, although it may not be as effective as prescribed sleep medication (Zhdanova I. 2005).

2. Problem Statement

Sleep adequacy includes, quality, timing and also duration. It has been estimated that the direct health cost of sleep disorder amounts to $1144 million Australian dollars in 2001 (NHS Aus. 2001), and 7.6% of the total motor vehicle accidents(MVA) in 2004 are indirectly caused by sleep disorders amounting to $808million net health costs. Studies have been done to show the benefits of exogenous melatonin for sleep disorders on individuals with intellectual disabilities and adolescence however very little has been done to show its effectiveness on the general population. Malaysia, has one of the highest rate of MVA in the world where according to Malaysian Institute of Road Safety (MIROS), from 1997 to 2007, there has been an increase of 59% of MVA and the main reason identified was driving fatigue due to awkward working hours/shift works (Kee et al. 2010). Availability of exogenous in Malaysia is scarce and it is not fully understood.

3. Research Question

1. How effective is exogenous melatonin in treating insomnia in general population?
2. How safe is exogenous melatonin?

4. Research Objective

1. To review efficacy of exogenous melatonin in treating insomnia
2. To access the safety of exogenous melatonin

5. Significance of Research

Data from available clinical trials and studies done on the efficacy of exogenous melatonin in insomnia will be compiled and compared to enable a more comprehensive and easily accessible result database. With the comprehensive database, clinicians will have a better understanding on the efficacy of MSCs and the best treatment option for the patient, thus improving patients quality of life.

How Much for a Paper?

Prices start at $10 per page for undergrad work and go up to $21 for advanced levels, depending on urgency and any extras you toss in. Deadlines range from a lightning-fast 3 hours to a chill 14 days—plenty of wiggle room there! Plus, if you’re ordering big, you’ll snag 5-10% off, making it easier on your wallet while still getting top-notch quality.

CHAPTER 2

LITERATURE REVIEW

2.1 INSOMNIA

Insomnia is often defined by the presence of an individual’s report of difficulty with sleep (Roth T 2007). The criteria often used in diagnosing insomnia includes i)difficulty falling asleep, staying asleep or nonrestorative sleep, ii) this opportunity is present despite adequate opportunity and circumstance to sleep, iii) this impairment in sleep is associated with daytime impairment or distress and iv) this sleep difficulty occurs at least 3 times per week and has been a problem for the past 1 month (Roth T 2007). The pathophysiology of insomnia can be due to the disorder of the hyper-arousal state throughout the whole day which causes alertness during the day and difficulty in falling or maintaining sleep (Stepanski E, 1988). A cross sectional study done on 156 US air force personal found that 40% suffered from sleep disorder and 75% reported diminished sleep quality while deployed overseas (Peterson AL, 2008). A study done in 2013 (Lentino et al, 2013) showed that 25% of the 14148 army and national guard personal reported to be poor sleepers thus affecting the quality of sleep and the quality of service.

Will Anyone Find Out I Used You?

Nope—your secret’s locked down tight. We encrypt all your data with top-tier security, and every paper’s crafted fresh just for you, run through originality checks to prove it’s one-of-a-kind. No one—professors, classmates, or anyone—will ever know you teamed up with us, guaranteed.

2.2 CURRENT TREATMENT FOR INSOMNIA

Currently the medications used for treating insomnias and other sleep disorders includes benzodiazepine receptor agonist (eg. Zolpidem, zipoclone) which are only limited to short term use (4 weeks) (Sanofi Aventis, 2007). The medication large affects the brain through the GABA receptors and long term use has been associated with memory and balance impairment, rebound imsomnia, withdrawal symptoms and abuse potential (Rush CR, 1999). Recent short termed studies have shown that discontinuation of the benzodiazepines lead to disruption of the sleep architecture and also increases sleep latency which makes withdrawing from treatment difficult (Mann K, 1996).

2.3 MELATONIN

Melatonin (5-methoxy-N-acetyltryptamine) is a lipid soluble hormone that is shown to be involved with the sleep physiology (Dijk D-J, 1997).it is also regulates the modulation of season change, in reproduction, antioxidant, oncostatic, anti inflammatory and anti-convulsant effect (Gitto E, 2013). Melatonin is mostly produced in the pineal gland in the brain during the hours of darkness and is involved in the regulation of the sleep-wake cycle (circadian cycle).the circadian process is maintained by the suprachiasmatic nucleus (SCN) which contains high number of melatonin receptors. During daytime, the SCN produces an arousal signal that maintains the wakefulness and prevents sleep drive however in darkness, there is a feedback loop which causes the release of melatonin which feeds back and inhibits the SCN (Geert et al, 2009) It has been documented that melatonin decreases with age especially in post menopausal women (Okatani Y, 2000). Other than to promote sleep, melatonin also shows sedative and anti-excitory effects (Hardeland R, 2008).

Do You Rely on AI?

Not even a little—our writers are real-deal experts with degrees, crafting every paper by hand with care and know-how. No AI shortcuts here; it’s all human skill, backed by thorough research and double-checked for uniqueness. You’re getting authentic work that stands out for all the right reasons.

2.4 EXOGENOUS MELATONIN

Exogenous melatonin has become one of the most frequently prescribed over the counter drug for those looking for non-prescription sleep medication (Wagner J, 1998). The exogenous melatonin is marketed to help promote quality sleep, helps in jet lag, or to regulate the circadian cycle due to jet lag or shift work due to its regulator role in the internal timing of biological rhythm. Some studies have shown that exogenous melatonin can help increase the sleep propensity although it may not be as effective as prescribed sleep medications (Zhdanova I, 2005). Studies have also been done regarding the use of exogenous melatonin in the treatment of sleep problems in individuals with sleep disability (Turk 2003) however there are still doubts on the efficacy of exogenous melatonin usage for the general public.

CHAPTER 3

METHODOLOGY

Why Are You Top for Research Papers?

Our writers are Ph.D.-level pros who live for nailing the details—think deep research and razor-sharp arguments. We pair that with top plagiarism tools, free revisions to tweak anything you need, and fast turnarounds that don’t skimp on quality. Your research paper won’t just shine—it’ll set the bar.

3.1 Research Design

This research was based on the PICOS guidelines :

Population (P): All types of insomnia patients

Intervention (I): Exogenous melatonin

Who’s Behind My Essays?

You’re in good hands with degree-holding pros—many rocking Master’s or higher—who’ve crushed our tough vetting tests in writing and their fields. They’re your partners in this, hitting tight deadlines and academic standards with ease, all while tailoring every essay to your exact needs. No matter the topic, they’ve got the chops to make it stellar.

Comparitor (C): Insomnia patients on treatment with exogenous melatonin

compared with other treatment by questionnaires

Outcome (O): Efficacy and safety of treatment

Study design (S): Randomized Controlled trials (RCT), Surveys

Is My Paper Original?

100%—we promise! Every paper’s written fresh from scratch—no AI, no copying—just solid research and proper citations from our expert writers. You can even request a plagiarism report to see it’s 95%+ unique, giving you total confidence it’s submission-ready and one-of-a-kind.

3.2 Database

Literature search was done on electronic articles/ journals in Central, PubMed and Google Scholar.

3.3 Keywords

Key words used to search articles with MESH terms were:

Can You Do Any Citation Style?

Yep—APA, Turabian, IEEE, Chicago, MLA, whatever you throw at us! Our writers nail every detail of your chosen style, matching your guidelines down to the last comma and period. It’s all about making sure your paper fits academic expectations perfectly, no sweat.

1. Insomnia
2. Exogenous melatonin

3.4 Quality Assessment

Quality assessment of the paper was done using Jadad scoring for randomized controlled trials (RCT) and Newcastle-Ottawa Scale (NOS) for case-control and cohort studies.

1.Jaded score assesses the quality of published clinical trials based on methods relevant to random assignment, double blinding and the flow of patients. There are 7 criteria evaluated, whereby 1 point is given if the criteria is met and the last 2 crietria carries a negative mark. Range of score is from 0 (bad) to 5 (good) (Jadad et al. 1996).

i. Was the study described as randomized (this include words such as randomly, random, and randomization)? [+1 point]

Can I Adjust Instructions Later?

Absolutely—life happens, and we’re flexible! Chat with your writer anytime through our system to update details, tweak the focus, or add new requirements, and they’ll pivot fast to keep your paper on point. It’s all about making sure the final draft is exactly what you need, no stress involved.

ii. Was the method used to generate the sequence of randomization described and appropriate (table of random numbers, computer generated etc)? [+1 point]

iii. Was the study described as double blind? [+1 point]

iv. Was the method of double blinding described and appropriate (identical placebo, active placebo, dummy, etc)? [+1 point]

v. Was there a description of withdrawals and dropouts? [+1point]

How Do I Get Started?

It’s super easy—order online with a few clicks, then track progress with drafts as your writer works their magic. Once it’s done, download it from your account, give it a once-over, and release payment only when you’re thrilled with the result. It’s fast, affordable, and built with students like you in mind!

vi. Deduct one point if the method used to generate the sequence of randomization was described and it was inappropriate (patients were allocated alternately, or according to date of birth, hospital number, etc)?

vii. Deduct one point if the study was described as double blind but the method of blinding was inappropriate (eg. comparison of table vs. injection with no double dummy)

2. Newcastle-Ottawa Scale (NOS) is developed to assess the quality of the non-randomized studies with its design, content and ease of use directed to the purpose of incorporating the quality assessments in the interpretation of the results. A ‘star system’ is developed to judge on 3 broad perspectives (Wells et al. 2014):

i. The selection of the study groups

How Fast for Rush Jobs?

We can crank out a killer paper in 24 hours—quality locked in, no shortcuts. Just set your deadline when you order, and our pros will hustle to deliver, even if you’re racing the clock. Perfect for those last-minute crunches without compromising on the good stuff.

ii. The comparability of the groups

3. The ascertainment of either the exposure or outcome of interest for case-control or cohort studies respectively

3.5 Inclusion and Exclusion Criteria

Inclusion criteria

Studies included in this review were chosen according to the flowing criteria :

i. Papers published in English language (2010-2015)

Can You Handle Complex Subjects?

For sure! Our writers with advanced degrees dive into any topic—think quantum physics or medieval lit—with deep research and clear, sharp writing. They’ll tailor it to your academic level, ensuring it’s thorough yet easy to follow, no matter how tricky the subject gets.

ii. All study designs were included to maximize the data collection

4. Study subjects includes all types of insomnia patients

Exclusion criteria

Studies that were done in foreign language and animal studies were excluded in this review

3.6 Ethical Clearance

The ethical committee of UCSI was notified regarding this thesis write-up

How Do You Meet Prof Standards?

We stick to your rubric like glue—nailing the structure, depth, and tone your professor wants—then polish it with edits for that extra shine. Our writers know what profs look for, and we double-check every detail to make sure it’s submission-ready and grade-worthy.

3.7 GAANT Chart

	DEC	JAN	FEB What’s Your Editing Like? Send us your draft and tell us your goals—we’ll refine it, tightening arguments and boosting clarity while keeping your unique voice intact. Our editors work fast, delivering pro-level results that make your paper pop, whether it’s a light touch-up or a deeper rework.	MAR	APR	MAY	JUN	JUL Can You Pick My Topic? Yes—we’ve got your back! We’ll brainstorm fresh, workable ideas tailored to your assignment, picking ones that spark interest and fit the scope. You choose the winner, and we’ll turn it into a standout paper that’s all yours.
Topic Selection
Literature Search
Proposal Write-up
Data Collection Do You Do Quick Revisions? Yep—need changes fast? We’ll jump on your paper and polish it up in hours, fixing whatever needs tweaking so it’s ready to submit with zero stress. Just let us know what’s off, and we’ll make it right, pronto.
Data Analysis
Thesis Write-up
Submission Can You Outline First? Sure thing! We’ll whip up a clear outline to map out your paper’s flow—key points, structure, all of it—so you can sign off before we dive in. It’s a handy way to keep everything aligned with your vision from the start.

3.8 Milestone

Proposal presentation: 27.02.2015

Submission: 31.03.2015

Data analysis complete: 30.05.2015

Thesis submission: 15.07.2015

REFERENCES

Can You Add Data or Graphs?

Absolutely—we’ll weave in sharp analysis or eye-catching visuals like stats and charts to level up your paper. Whether it’s crunching numbers or designing a graph, our writers make it professional and impactful, tailored to your topic.

1. CATHERINE CORNU, L. R., FLORENCE NOEL-BARON, ALAIN NICOLAS, NATHALIE FEUGIER-FAVIER, PASCAL ROY, & BRUNO CLAUSTRAT, M. S.-E. A. B. K. 2010. A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial. BMC Complementary and Alternative Medicine, 10.

2. SZESEEN KEE, S. B. M. T., YONGMENG GOH 2010. Driving Fatigue and Performance among Occupational Drivers in Simulated Prolonged Driving. Global Journal of Health Science, 2.

3. REBECCA B COSTELLO, C. V. L., COURTNEY C BOYD, MEGHAN L O’CONNELL, CINDY C CRAWFORD, & DEUSTER, M. L. S. A. P. A. 2014. The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutrition Journal, 13.

4. DAVID R HILLMAN, M., FRCPE, FANZCA; ANITA SCOTT MURPHY, BEC; RAL ANTIC, MB, FRACP; LYNNE PEZZULLO, BEC 2006. The Economic Cost of Sleep Disorders. Sleep, 29.

5. GEERT MAYER, M. S. W.-W., MD, PHD; BARBARA ROTH-SCHECHTER, PHD; REINER LEHMANN, MD; CORINNE STANER, MD; MARKKU PARTINEN, MD, PHD 2009. Efficacy and Safety of 6-Month Nightly Ramelteon Administration in Adults with Chronic Primary Insomnia. Sleep, 32.

6. FRANK A.J.L. SCHEER, P. C. J. M., PHD; JOANNA I. GARCIA, BA; CAROLINA SMALES, BSC; ERIN E. KELLY, MSC; JENNY MARKS, MPH; & ATUL MALHOTRA, M. S. A. S., PHD 2012. Repeated Melatonin Supplementation Improves Sleep in Hypertensive Patients Treated with Beta-Blockers: A Randomized Controlled Trial. Sleep, 35.

7. JONATHAN J. BASKETT, J. B. B., PHILIP C. WOOD, JOHN R. DUNCAN,MEGAN J. PLEDGER, JUDIE ENGLISH, JOSEPHINE ARENDT 2003. Does melatonin improve sleep in older people? A randomised crossover trial. Age and Aging, 32, 164-170.

8. P GRINGRAS, C. G., A P JONES , L WIGGS , P R WILLIAMSON , A SUTCLIFFE , P MONTGOMERY, W P WHITEHOUSE , I CHOONARA, A EDMOND, R APPLETON 2012. Melatonin for sleep problems in children with neurodevelopmental disorders: randomised doubl emasked placebo controlled trial. BMJ, 354.

9. LIIRA J, V. J., COSTA G, DRISCOLL TR, SALLINEN M, ISOTALO LK, RUOTSALAINEN JH 2014. Pharmacological interventions for sleepiness and sleep disturbances caused by shift work (Review). The Cochrane Collaboration.

10. VENKATARAMANUJAM SRINIVASAN, D. D. B., TIMO PARTONEN,RAHIMAH ZAKARIA,ZAHIRUDDIN OTHMAN 2014. The use of melatonin for treating sleep disorders in patients with Parkinson’s disease. ChronoPhysiology and Therapy, 51-57.

How Do You Manage Big Projects?

We tackle each chunk with precision, keeping quality consistent and deadlines on track from start to finish. Whether it’s a dissertation or a multi-part essay, we stay in sync with you, delivering top-notch work every step of the way.

11. THOMAS ROTH 2007. Insomnia: Definition, Prevalence, Etiology, and Consequences. Supplement, 3

12. LUCIA MARSEGLIA, G. D. A., SARA MANTI, SALVATORE AVERSA , TERESA ARRIGO, RUSSEL J. REITER, ELOISA GITTO 2015. Analgesic, Anxiolytic and Anaesthetic Effects of Melatonin: New Potential Uses in Pediatrics. Int. J. Mol. Sci., 1209-1220.

13. SCHWAB, N. S. G. P. G. I. G. E. A.-S. E. M. R. 2010. Effectiveness of Ramelteon for Insomnia Symptoms in Older Adults with Obstructive Sleep Apnea: A Randomized Placebo- Controlled Pilot Study. Journal of Clinical Sleep Medicine, 6

14. ROSEANNE DEFRONZO DOBKIN, M. M., KARINA L. BIENFAIT, LESLEY A. ALLEN, HUMBERTO MARIN, AND MICHAEL A. GARA 2009. Ramelteon for the treatment of insomnia in menopausal women. Menopause Int., 15, 13-18.

15. JAMIE M. ZEITZER, B. K., DOUG OTA, B. JENNY KIRATLI 2014. Randomized controlled trial of pharmacological replacement of melatonin for sleep disruption in individuals with tetraplegia. The Journal of Spinal Cord Medicine, 37.

16. GIULIANA GALLI-CARMINATIA, N. D., GILLES BERTSCHY 2009. Melatonin in the treatment of chronic sleep disorders in adults with autism: a retrospective study. S W i S S M e d W k ly, 139, 293-296.

Tags: Best Essay Writing Website for PhD Essays, Cheap Dissertation Writer USA and UK, Custom Essay and Assignment Writing Australia, Doctoral Dissertation Writing Service China