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Posted: March 30th, 2023
Describe the dominant oncogene expressed in the virus
Question description
Rous Sarcoma Virus (RSV) is called an "acutely
transforming retrovirus" since the viral genome contains a
cellular oncogene called Src. Besides RSV,
over 40 naturally occurring acutely transforming retroviruses have been isolated
in nature that also carry cellular oncogenes. Five of these viruses are listed below. For each virus, (i) describe
the dominant oncogene expressed in the
virus, and (ii) briefly outline the mechanisms by which these oncogenes transform cells.
1. Abelson murine leukemia virus
2. Fujinami sarcoma virus
3. Avian sarcoma virus CT10
4. Harvey murine sarcoma virus
5. Moloney murine leukemia virus
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